'London Patient' Is Second Person Ever to Be Cured of HIV

  • 'London Patient' Is Second Person Ever to Be Cured of HIV

'London Patient' Is Second Person Ever to Be Cured of HIV

Still, the news has rekindled hopes of finally winning the war against the virus that causes AIDS. The Berlin patient also had some form of blood cancer. Some bits of HIV genetic material were detected in long-lived memory T cells, but Gupta said these are probably "fossils" that can not trigger active viral replication.

"It's a long way away. But it gives you the sense that it might be worth putting in the effort to see if we can develop the technologies to make that happen", Johnston said. "Our findings show that the success of stem cell transplantation as a cure for HIV, first reported nine years ago in the Berlin patient, can be replicated", said lead author on the study, Professor Ravindra Kumar Gupta at the University of Cambridge, UK. In 2012, doctors found he also had advanced Hodgkin's Lymphoma, a deadly cancer.

To ensure that the HIV is really gone, experts had conducted viral tests of Adam's cerebral fluid, intestinal tissue and lymphoid tissue after more than two years of stopping antiretroviral treatment. In other words, the donor was resistant to HIV.

HIV is spread by contact with body fluids of a person infected with HIV.

These were longer-term findings, where researchers examined samples from "diverse HIV reservoir sites", including viral load assays of plasma, semen, and CSF to detect HIV RNA, and gut biopsy samples and lymph-node tissue to detect cell-copy number and HIV DNA levels.

Transplants are unsafe and may not be a realistic treatment at this time.

The problems with applying this exact cure to everyone now living with HIV are numerous. Mr. Castillejo told the New York Times: "This is a unique position, a unique and very humiliating position".

Brown's HIV was cured after he underwent a procedure known as a hematopoietic stem cell transplantation to treat his leukemia in 2007.

He spent months in the hospital, having received multiple operations. "To scale that up to other patients would be hard".

Importantly, Castillejo had a less intensive treatment procedure than the Berlin patient, with a gentler chemotherapy regimen - without whole body irradiation - and a single transplant procedure.

Although most people with HIV can manage the virus with now available antivirals and live a long life, experimental research of this kind can provide insight into how a cure might be developed.

But there are important lessons to be learned from the men cured of HIV infection in this way.

The long-term data comes after the researchers had initially reported no trace of HIV after 18 months. I was in the right place, probably at the right time, when it happened.

The labels have been added to this press release as part of a project run by the Academy of Medical Sciences seeking to improve the communication of evidence.

In 2016 he underwent a bone marrow transplant, in which he received stem cells from donors who have a highly rare genetic mutation that prevents HIV from taking hold. Researchers continue to follow this third patient. He was declared HIV-free three and half years after having the treatment.

All of this points toward a potential gene therapy cure for HIV, Johnston said. The cells in Castillejo's immune system were replaced with donor cells with the Delta 32 mutation. "I do recall when the person told me and the panic set in".

Castillejo has become the second person to be cured of HIV.