What Causes PCOS? Scientists May Have Finally Found an Answer

  • What Causes PCOS? Scientists May Have Finally Found an Answer

What Causes PCOS? Scientists May Have Finally Found an Answer

Beyond helping women to get pregnant, this is an wonderful breakthrough for those frustrated with the side effects from the condition, because they may at long last have relief.

Researchers in France believe PCOS could be caused by the fetus being overexposed to a hormone known as anti-Müllerian (AMH).

Researchers of the new study published in the journal Nature Medicine measured the hormone levels of pregnant women with and without PCOS, and found that pregnant women who have PCOS have 30 percent higher levels of an anti-Mullerian hormone (AMH) than normal.

PCOS effects up to 5 million USA women, according to the CDC, and those with PCOS have higher levels of male hormones called androgens, which can result in the absence of ovulation (leading to infertility).

"These findings highlight a critical role for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood", the researchers wrote. As the offspring grew up, the scientists found they had many symptoms of PCOS, including infrequent ovulation and fertility struggles. In women, this can include irregular periods, excess ance and hair growth on the body and face, as well as ovarian cysts. Dr. Paolo Giacobini, head scientist of this study, and his team hope to start human trials by the end of the year.

And the team weren't just able to determine the cause of PCOS, they reversed it into mice.

PCOS infertility cure

"It is by far the most common hormonal condition that affects women of reproductive age, but it hasn't received a lot of attention", Robert Norman at the University of Adelaide in Australia told the New Scientist. In this condition, the ovary or ovaries develop multiple fluid-filled sacs that contain immature eggs that do not mature for ovulation.

They explained that the excess hormone appeared to overstimulate a set of brain cells that raises testosterone levels.

The researchers dosed the polycystic mice with an IVF drug called cetrorelix, which made the symptoms go away.

Previous research has suggested that a diet with a low glycemic index - the GI diet - could ease symptoms by controlling the amount of insulin produced by the body.

PCOS sufferers should have a healthy diet, including at least five portions of fruit and vegetables a day, lean meat and fish, and dairy products, while avoiding anything too fatty or sugary.