Ibuprofen linked to male infertility in study

  • Ibuprofen linked to male infertility in study

Ibuprofen linked to male infertility in study

Within 14 days, the men taking daily ibuprofen exhibited an increase in luteinising hormones - which help regulate testosterone production - indicating the drug had impaired healthy testicular function, forcing the body to compensate by boosting testosterone levels.

Taking the common painkiller ibuprofen has been linked in a small study with a condition affecting male fertility problems.

Dr David Kristensen, of Copenhagen University, said: "Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism" - a condition prevalent among elderly men and associated with reproductive and physical disorders".

As per the researchers, when used for a short time, ibuprofen has reversible effects but in the longer run, it is not known whether the effects are reversible or irreversible.

During the last few decades, many other similar painkillers have been associated with health risks such as Acetaminophen, which is a common household drug for the American population. This is the hormone that's secreted by the pituitary gland and stimulates the production of testosterone which plays important role in fertility. Ibuprofen is taken nearly routinely by young athletes for injuries and pain.

To find out, researchers recruited 31 male participants aged between 18 and 35, giving half of them a moderate dose (600 milligrams, equivalent to three tablets) of the drug daily for six weeks, while the other group took a placebo. He said that the safety of Ibuprofen has been proven by decades of study and real-world use.

Previous research by the team, which focused on pregnant women, had found that the use of Paracetamol and Ibuprofen during pregnancy affected the testicles of male babies. So, for the time being, I would urge men who need to take ibuprofen to continue to do so.

"This comprehensive meta-regression analysis reports a significant decline in sperm counts (as measured by SC and TSC) between 1973 and 2011, driven by a 50-60% decline among men unselected by fertility from North America, Europe, Australia and New Zealand". "It is sure that these effects are reversible", he said.

"People taking over-the-counter ibuprofen should not be concerned by this research". In a recent study by researchers, ibuprofen has been contributing to the deterioration of male fertility upon long-term exposure. So it's not much cause for concern for the occasional user (even high doses over a week-ling time frame would likely not lead to permanent hormonal changes, according to the study authors).